In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs,
contributing to resistance to therapies. This includes a higher demand for cholesterol, which …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid
malignancies, which is featured by systematic metabolism. Thus, a better understanding of …

Pancreatic ductal adenocarcinoma (PDAC) is an uncommon but highly fatal malignancy.
Identifying causal metabolite biomarkers offers an opportunity to facilitate effective risk …

Alzheimer's disease (AD) is a common neurodegenerative disease in aging individuals.
Alternative splicing is reported to be relevant to AD development while their roles in etiology …

Purpose It is critical to identify putative causal targets for SARS coronavirus 2, which may
guide drug repurposing options to reduce the public health burden of COVID-19. Methods …

Prior observational studies suggest an association between intra-pancreatic fat deposition
(IPFD) and pancreatic ductal adenocarcinoma (PDAC); however, the causal relationship is …

Specific metabolites have been reported to be potentially associated with Alzheimer's
disease (AD) risk. However, the comprehensive understanding of roles of metabolite …

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor
prognosis is predominantly due to the fact that most patients remain asymptomatic until the …

A large proportion of heritability for prostate cancer risk remains unknown. Transcriptome‐
wide association study combined with validation comparing overall levels will help to identify …