Since the first discovery of an inverse correlation between high‐density lipoprotein‐
cholesterol (HDL‐C) levels and coronary heart disease in the 1950s the life cycle of HDL, its …

Context and Objective: In most populations a greater proportion of men have hepatic
steatosis than women. Sex-specific differences in hepatic dietary fatty acid (FA) metabolism …

Liver X receptors α (LXRα) and β (LXRβ) are essential for protection against cardiovascular
diseases. LXRs are members of the nuclear receptor superfamily of DNA-binding …

Activation of liver X receptors (LXRs) by synthetic agonists was found to improve cognition in
Alzheimer's disease (AD) mice. However, these LXR agonists induce hypertriglyceridemia …

Combination antiretroviral therapy has dramatically changed the outcome of HIV infection,
turning it from a death sentence to a manageable chronic disease. However, comorbidities …

Alzheimer disease (AD) is characterized by the extracellular accumulation of amyloid β (Aβ),
which is accompanied by a robust inflammatory response in the brain. Both of these …

Aim Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality
for patients with type 2 diabetes mellitus and obesity, based on preclinical data suggesting it …

Macrophages are involved in the whole process of atherosclerosis, which is characterized
by accumulation of lipid and inflammation. Presently, clinically used lipid-lowering drugs …

Liver X receptors (LXR) are stimulated by cholesterol-derived oxysterols and serve as
transcription factors to regulate gene expression in response to alterations in cholesterol. In …

LXRs have been of interest as targets for the treatment of atherosclerosis for over a decade.
In recent years, LXR modulators have also garnered interest for potential use in the …