How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …

Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia,
measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains< …

The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in
the gene encoding methyl-CpG binding protein 2 (MeCP2), a transcriptional repressor …

Loss of E-cadherin is a key initial step in the transdifferentiation of epithelial cells to a
mesenchymal phenotype, which occurs when tumor epithelial cells invade into surrounding …

ε-N-acetylation of lysine residues (Kac) is one of the most abundant post-translation
modifications (PTMs) in the human proteome. In the nucleus, acetylation of histones has …