The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis
CJ Queval, R Brosch, R Simeone - Frontiers in microbiology, 2017 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …
plagued humans for thousands of years. TB still remains a major public health problem in …
Drug resistance in nontuberculous mycobacteria: mechanisms and models
S Saxena, HP Spaink, G Forn-Cuní - Biology, 2021 - mdpi.com
Simple Summary Recently, there has been a considerable rise in infections caused by
nontuberculous mycobacteria (NTM). These mycobacteria, which comprise a large and …
nontuberculous mycobacteria (NTM). These mycobacteria, which comprise a large and …
Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules
AD Bondarev, MM Attwood, J Jonsson… - Frontiers in …, 2022 - frontiersin.org
The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal
transduction system, are long-established as attractive therapeutic targets. During …
transduction system, are long-established as attractive therapeutic targets. During …
Perspective for precision medicine for tuberculosis
Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to
human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an …
human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an …
Protection and pathology in TB: learning from the zebrafish model
AH Meijer - Seminars in immunopathology, 2016 - Springer
Zebrafish has earned its place among animal models of tuberculosis. Its natural pathogen,
Mycobacterium marinum, shares major virulence factors with the human pathogen …
Mycobacterium marinum, shares major virulence factors with the human pathogen …
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
H Kim, SJ Shin - Cellular and Molecular Life Sciences, 2023 - Springer
Lipid species play a critical role in the growth and virulence expression of Mycobacterium
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …
Repurposing tamoxifen as potential host-directed therapeutic for tuberculosis
R Boland, MT Heemskerk, G Forn-Cuní, CJ Korbee… - MBio, 2023 - Am Soc Microbiol
The global burden of tuberculosis (TB) is aggravated by the continuously increasing
emergence of drug resistance, highlighting the need for innovative therapeutic options. The …
emergence of drug resistance, highlighting the need for innovative therapeutic options. The …
[HTML][HTML] The antimicrobial activity of innate host-directed therapies–a systematic review
Intracellular human pathogens are the deadliest infectious diseases and pose great difficulty
to effectively treat due to their protection inside the host cell and the development of …
to effectively treat due to their protection inside the host cell and the development of …
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis
Tobacco smoking doubles the risk of active tuberculosis (TB) and accounts for up to 20% of
all active TB cases globally. How smoking promotes lung microenvironments permissive to …
all active TB cases globally. How smoking promotes lung microenvironments permissive to …
Host-directed therapy as a novel treatment strategy to overcome tuberculosis: targeting immune modulation
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in
developing countries, presenting a major threat to the public health. The currently …
developing countries, presenting a major threat to the public health. The currently …