Abstract Development of the forebrain critically depends on the Sonic Hedgehog (Shh)
signaling pathway, as illustrated in humans by the frequent perturbation of this pathway in …

Cells need to sense their mechanical environment during the growth of developing tissues
and maintenance of adult tissues. The concept of force-sensing mechanisms that act …

Blood flow shapes vascular networks by orchestrating endothelial cell behavior and
function. How endothelial cells read and interpret flow-derived signals is poorly understood …

Objective Physiological mechanical loading reduces inflammatory signalling in numerous
cell types including articular chondrocytes however the mechanism responsible remains …

Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular
signalling and motility. Intraflagellar transport (IFT) contributes to the formation of the highly …

Centrosome amplification is a hallmark of cancer, and centrosome clustering is essential for
cancer cell survival. The mitotic kinesin HSET is an essential contributor to this process …

Ciliary transport in eukaryotic cells is an intricate and conserved process involving the
coordinated assembly and functioning of a multiprotein intraflagellar transport (IFT) complex …

The mitotic regulator, Aurora kinase B (AURKB), is frequently overexpressed in malignancy
and is a target for therapeutic intervention. The compound, LXY18, is a potent, orally …

Cytokinesis is a mechanism that separates dividing cells via constriction of a supramolecular
structure, the contractile ring. In animal cells, three modes of symmetry-breaking of …

Cytokinesis plays crucial roles in morphogenesis. Previous studies have examined how
tissue mechanics influences the position and closure direction of the contractile ring …