Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

Liver fibrosis occurs as a compensatory response to the process of tissue repair in a wide
range of chronic liver injures. It is characterized by excessive deposition of extracellular …

Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis within solid
cancers. Thus, targeting VEGF might be part of a feasible therapy for treating pathological …

Scorpion sting is one of the most important problems in public health practice in many
countries. Khuzestan yellow scorpion, scientifically known as Hemiscorpius lepturus …

Angiogenesis is among the most important mechanisms that helps cancer cells to survive,
grow and undergo metastasis. Therefore, inhibiting angiogenesis will suppress tumor …

Solid cancers are affiliate on angiogenesis for preservation. The FDA-approved monoclonal
antibodies like Bevacizumab are currently being administered effectively as inhibitors of …

The potency of VEGF-based anti-angiogenic strategies in cancer therapy and the brilliant
characteristics of VHHs motivated us to directly block VEGF binding to its receptor with …

Angiogenesis is a hallmark of various pathological conditions and is controlled by a variety
of angiogenic factors. Blockade of vascular endothelial growth factor (VEGF) as the most …

Background: Inhibition of angiogenesis using monoclonal antibodies is an effective strategy
in cancer therapy. However, they could not penetrate sufficiently into solid tumors. Antibody …

The present study aimed to develop a quick and efficient method for purification of newborn
endothelial cells from tumor tissues. Fresh tissues were separated from C57BL/6 mice …