Achieving complete understanding of any living thing inevitably requires thorough analysis
of both its anatomic and dynamic properties. Live-cell imaging experiments carried out to …

The past decade has seen an unprecedented data explosion in biology. It has become
evident that in order to take full advantage of the potential wealth of information hidden in the …

Cell segmentation and tracking in time-lapse fluorescence microscopy images is a task of
fundamental importance in many biological studies on cell migration and proliferation. In …

Quantitative analysis of biological image data generally involves the detection of many
subresolution spots. Especially in live cell imaging, for which fluorescence microscopy is …

Variational deformable models have proven over the past decades a high efficiency for
segmentation and tracking in 2-D sequences. Yet, their application to 3-D time-lapse images …

Meiotic chromosome segregation requires homologue pairing, synapsis, and crossover
recombination, which occur during meiotic prophase. Telomere-led chromosome motion has …

Modern automated microscopes collect digital images at an astonishing pace. Automated
image analysis can measure biological phenotypes quantitatively and reliably, and has …

Background Cell motility is a critical parameter in many physiological as well as
pathophysiological processes. In time-lapse video microscopy, manual cell tracking remains …

The direct observation of cells over time using time-lapse microscopy can provide deep
insights into many important biological processes. Reliable analyses of motility, proliferation …

Autofocusing is a routine technique in redressing focus drift that occurs in time-lapse
microscopic image acquisition. To date, most automatic microscopes are designed on the …