There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

In this work, N-benzylarylamide-dithiocarbamate based derivatives were designed,
synthesized, and their biological activities as anticancer agents were explored. Some of the …

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin
polymerization inhibitors targeting the colchicine binding site. Among these compounds …

A new series of vinyl amide-, imidazolone-, and triazinone-linked combretastatin A-4
analogues have been designed and synthesised. These compounds have been evaluated …

Microtubules, formed by α-and β-tubulin heterodimer, are considered as a major target to
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …

Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

Tremendous research is focused on developing novel drug candidates targeting
microtubules to inhibit their function in several cellular processes, including cell division. In …

Parthenolide (PTL) is a sesquiterpene lactone derived from medicinal plant feverfew
(Tanacetum parthenium). Recent studies have demonstrated that it has multiple …

Epigenetic regulation and Focal adhesion kinase (FAK) are considered to be two important
targets for the development of antitumor drugs. Studies have shown that the combination of …