Virulence factors of the Mycobacterium tuberculosis complex

MA Forrellad, LI Klepp, A Gioffré, J Sabio y Garcia… - Virulence, 2013 - Taylor & Francis
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Advances in protein subunit vaccines against tuberculosis

Y Zhang, J Xu, Z Hu, X Fan - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB), also known as the “White Plague”, is caused by Mycobacterium
tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any …

Function Prediction and Analysis of Mycobacterium tuberculosis Hypothetical Proteins

GK Mazandu, NJ Mulder - International journal of molecular sciences, 2012 - mdpi.com
High-throughput biology technologies have yielded complete genome sequences and
functional genomics data for several organisms, including crucial microbial pathogens of …

An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary …

S Commandeur, KE Van Meijgaarden… - The Journal of …, 2013 - journals.aai.org
Mycobacterium tuberculosis is responsible for almost 2 million deaths annually.
Mycobacterium bovis bacillus Calmette-Guérin, the only vaccine available against …

Genome-Wide Discovery of Small RNAs in Mycobacterium tuberculosis

P Miotto, F Forti, A Ambrosi, D Pellin, DF Veiga… - PLoS one, 2012 - journals.plos.org
Only few small RNAs (sRNAs) have been characterized in Mycobacterium tuberculosis and
their role in regulatory networks is still poorly understood. Here we report a genome-wide …

Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis

C Sao Emani, MJ Williams, IJ Wiid… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Ergothioneine (ERG) and mycothiol (MSH) are two low-molecular-weight thiols synthesized
by mycobacteria. The role of MSH has been extensively investigated in mycobacteria; …

ppe51 Variants Enable Growth of Mycobacterium tuberculosis at Acidic pH by Selectively Promoting Glycerol Uptake

SJ Dechow, JJ Baker, M Murto… - Journal of …, 2022 - Am Soc Microbiol
In defined media supplemented with single carbon sources, Mycobacterium tuberculosis
(Mtb) exhibits carbon source specific growth restriction. When supplied with glycerol as the …

Characterization of the Mycobacterium tuberculosis Proteome by Liquid Chromatography Mass Spectrometry-based Proteomics Techniques: A Comprehensive …

C Bell, GT Smith, MJ Sweredoski… - Journal of proteome …, 2012 - ACS Publications
Approximately, one-third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of Tuberculosis. Secreted and membrane proteins that …

Regulation of host cell pyroptosis and cytokines production by Mycobacterium tuberculosis effector PPE60 requires LUBAC mediated NF-κB signaling

Z Gong, Z Kuang, H Li, C Li, MK Ali, F Huang, P Li… - Cellular …, 2019 - Elsevier
Tuberculosis, caused by Mycobacterium tuberculosis infection, remains a global public
health threat. The success of M. tuberculosis largely contributes to its manipulation of host …