Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Ezrin, as encoded by the EZR gene, is a member of the Ezrin/Radixin/Moesin (ERM) family.
The ERM family includes three highly related actin filament binding proteins, Ezrin, Radixin …

EZR, a member of the ezrin-radixin-moesin (ERM) family, is involved in multiple aspects of
cell migration and cancer. SMYD3, a histone H3–lysine 4 (H3–K4)-specific …

Cancer metastasis is the primary cause of morbidity and mortality in cancer as it remains the
most complicated, devastating, and enigmatic aspect of cancer. Several decades of …

This study aimed to assess the apoptosis-inducing mechanism of zinc oxide nanoparticles
(ZnO NPs) stabilized by Solanum xanthocarpum plant extract in human osteosarcoma MG63 …

Abstract miR‑552 promotes tumor growth and metastasis in colorectal cancer. However, the
function of miR‑552 in osteosarcoma remains unclear. The current study investigated the …

Abstract Background Upregulation of microRNA-221 (miR-221) has been reported to induce
the malignant phenotype of human osteosarcoma, suggesting its potential as a therapeutic …

Spheroid cell culture emerges as powerful in vitro tool for experimental tumour research. In
this study, we established a scaffold‐free three‐dimensional spheroid system built from …

Osteosarcoma (OS) represents the main cancer affecting bone tissue, and one of the most
frequent in children. In this review we discuss the major pathological hallmarks of this …

Sarcoma includes some of the most heterogeneous tumors, which make the diagnosis,
prognosis and treatment of these rare yet diverse neoplasms especially challenging. Long …