The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …

Background: Recently, loss-of-function variants in TLR7 were identified in two families in
which COVID-19 segregates like an X-linked recessive disorder environmentally …

The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

Tumour microenvironment is a complex, multicellular functional compartment that,
particularly when assembled as an abundant desmoplastic reaction, may profoundly affect …

The liver is considered a preferential tissue for NK cells residency. In humans, almost 50% of
all intrahepatic lymphocytes are NK cells that are strongly imprinted in a liver-specific …

Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Gastrointestinal cancer is one of the leading health problems worldwide, with a high
morbidity and mortality. To date, harnessing both the innate and adaptive immune system …

The liver is a lymphoid organ with unique immunological properties, particularly, its
predominant innate immune system. The balance between immune tolerance and immune …