Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
The plasticity of mRNA translation during cancer progression and therapy resistance
L Fabbri, A Chakraborty, C Robert, S Vagner - Nature Reviews Cancer, 2021 - nature.com
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
Ribosome biogenesis in cancer: new players and therapeutic avenues
J Pelletier, G Thomas, S Volarević - Nature Reviews Cancer, 2018 - nature.com
The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …
[HTML][HTML] MYC on the path to cancer
CV Dang - Cell, 2012 - cell.com
The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …
its expression and function have led to therapeutic opportunities. MYC's activation by …
First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study
Abstract RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly
regulated downstream of oncogenic pathways, and its dysregulation is a common feature in …
regulated downstream of oncogenic pathways, and its dysregulation is a common feature in …
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
LS Hart, JT Cunningham, T Datta, S Dey… - The Journal of …, 2012 - Am Soc Clin Investig
The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the
pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood …
pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood …
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical
management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX …
management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX …
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity
K Peltonen, L Colis, H Liu, R Trivedi, MS Moubarek… - Cancer cell, 2014 - cell.com
We define the activity and mechanisms of action of a small molecule lead compound for
cancer targeting. We show that the compound, BMH-21, has wide and potent …
cancer targeting. We show that the compound, BMH-21, has wide and potent …
[HTML][HTML] Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
Increased transcription of ribosomal RNA genes (rDNA) by RNA Polymerase I is a common
feature of human cancer, but whether it is required for the malignant phenotype remains …
feature of human cancer, but whether it is required for the malignant phenotype remains …