[HTML][HTML] Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

S Haddadzadegan, F Dorkoosh… - Advanced drug delivery …, 2022 - Elsevier
The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Non-invasive delivery strategies for biologics

AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …

Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration

S Hua - Frontiers in pharmacology, 2019 - frontiersin.org
The sublingual and buccal routes of administration have significant advantages for both
local and systemic drug delivery. They have shown to be an effective alternative to the …

Ionic liquid-mediated delivery of insulin to buccal mucosa

A Vaidya, S Mitragotri - Journal of Controlled Release, 2020 - Elsevier
Buccal drug delivery offers a potential non-invasive means of delivering therapeutics to
patients. Despite the promise, the feasibility of transporting proteins and peptides into …

An updated overview of the emerging role of patch and film-based buccal delivery systems

S Jacob, AB Nair, SHS Boddu, B Gorain, N Sreeharsha… - Pharmaceutics, 2021 - mdpi.com
Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …

Novel and revisited approaches in nanoparticle systems for buccal drug delivery

AS Macedo, PM Castro, L Roque, NG Thomé… - Journal of Controlled …, 2020 - Elsevier
The buccal route is considered patient friendly due to its non-invasive nature and ease of
administration. Such delivery route has been used as an alternative for the delivery of drugs …

Evaluation of photodynamic therapy on nanoparticles and films loaded-nanoparticles based on chitosan/alginate for curcumin delivery in oral biofilms

ALP Silvestre, AM Dos Santos, AB de Oliveira… - International Journal of …, 2023 - Elsevier
Nanoparticles and nanoparticle-loaded films based on chitosan/sodium alginate with
curcumin (CUR) are promising strategies to improve the efficacy of antimicrobial …

Methacrylated chitosan as a polymer with enhanced mucoadhesive properties for transmucosal drug delivery

OM Kolawole, WM Lau, VV Khutoryanskiy - International Journal of …, 2018 - Elsevier
Chitosan is a cationic polysaccharide that exhibits mucoadhesive properties which allow it to
adhere to mucosal tissues. In this work, we explored chemical modification of chitosan …

Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles–an update

VV Nair, P Cabrera, C Ramírez-Lecaros… - International Journal of …, 2023 - Elsevier
Buccal delivery of small and large molecules is an attractive route of administration that has
been studied extensively over the past few decades. This route bypasses first-pass …

Advances in buccal and oral delivery of insulin

A Elsayed, M Al-Remawi, N Jaber… - International Journal of …, 2023 - Elsevier
Diabetes mellitus is a metabolic endocrine disease characterized by chronic hyperglycemia
with disturbances in metabolic processes, such as those related to carbohydrates, fat, and …