Use of activation and recovery times and dispersions to monitor heart failure status and arrhythmia risk

JE Burnes - US Patent 7,107,093, 2006 - Google Patents
A system and method for monitoring electrical dispersion of the heart is provided including
an implantable medical device and associated electrode system for sensing cardiac signals …

Basis and ECG measurement of global ventricular repolarization

RL Lux - Journal of Electrocardiology, 2017 - Elsevier
Ventricular repolarization and its manifestation in the T wave of the electrocardiogram have
long been a focus of clinical and experimental electrocardiology. In this short article, we …

Spatial dispersion of repolarization is a key factor in the arrhythmogenicity of long QT syndrome

M Restivo, EB Caref, DO Kozhevnikov… - Journal of …, 2004 - Wiley Online Library
Introduction: The occurrence of significant spatial dispersion of repolarization in vivo as it
relates to the mechanism of arrhythmia formation in the long QT syndrome (LQTS) continues …

Geometrical considerations in cardiac electrophysiology and arrhythmogenesis

J Winter, MJ Shattock - Europace, 2016 - academic.oup.com
The rate of repolarization (R Repol) and so the duration of the cardiac action potential are
determined by the balance of inward and outward currents across the cardiac membrane …

System and method for treating abnormal ventricular activation-recovery time

LP Weinberg, PA Levine - US Patent 6,970,743, 2005 - Google Patents
An implantable cardiac Stimulation device provides long QT interval therapy for preventing
abnormal ventricular activa tion-recovery time and ultimately ventricular arrhythmias. The …

The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of …

D Izumi, M Chinushi, K Iijima, H Furushima, Y Hosaka… - Heart Rhythm, 2012 - Elsevier
BACKGROUND: Previous studies have showed that the interval between the peak and the
end of the T wave (Tp-e) is a marker of transmural dispersion of ventricular repolarization …

Role of α1-Blockade in Congenital Long QT Syndrome Investigation by Exercise Stress Test

H Furushima, M Chinushi, T Washizuka… - Japanese circulation …, 2001 - jstage.jst.go.jp
Beta-blockade is widely reported to reduce the incidence of syncope in 75–80% of patients
with congenital long QT syndrome (LQTS). However, despite full-doseβ-blockade, 20–25 …

Triggers of ventricular tachyarrhythmias and therapeutic effects of nicorandil in canine models of LQT2 and LQT3 syndromes

M Chinushi, H Kasai, M Tagawa, T Washizuka… - Journal of the American …, 2002 - jacc.org
Objectives: We sought to identify the triggers of ventricular tachyarrhythmia (VTA) in
experimental models of long QT type 2 (LQT2) and long QT type 3 (LQT3) syndromes …

Adaptation of ventricular repolarization duration and dispersion during changes in heart rate induced by atrial stimulation

KJ Axelsson, A Brännlund, L Gransberg… - Annals of …, 2020 - Wiley Online Library
Background The duration of ventricular repolarization (VR) and its spatial and temporal
heterogeneity are central elements in arrhythmogenesis. We studied the adaptation of VR …

Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome

M Chinushi, D Izumi, K Iijima, S Ahara, S Komura… - Europace, 2008 - academic.oup.com
Aims The effects of adrenergic activity and beta-blockade were studied in a canine
experimental model of type-3 long QT syndrome (LQT3) induced by application of …