Glioma targeted therapy: insight into future of molecular approaches

K Yang, Z Wu, H Zhang, N Zhang, W Wu, Z Wang… - Molecular Cancer, 2022 - Springer
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts

Y Wang, H Zhang, C Liu, Z Wang, W Wu… - Journal of Hematology & …, 2022 - Springer
The discovery of immune checkpoint inhibitors (ICIs) has now been universally
acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of …

Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends

Q Sun, Z Hong, C Zhang, L Wang, Z Han… - Signal transduction and …, 2023 - nature.com
Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment

Z Gao, Y Bai, A Lin, A Jiang, C Zhou, Q Cheng, Z Liu… - Molecular Cancer, 2023 - Springer
As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma

H Zhang, N Zhang, W Wu, R Zhou, S Li… - Briefings in …, 2022 - academic.oup.com
Long noncoding ribonucleic acids (RNAs; lncRNAs) have been associated with cancer
immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma …

Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options

Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance

X Ma, S Jia, G Wang, M Liang, T Guo, H Du… - Signal transduction and …, 2023 - nature.com
Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer
(GC). Understanding the upstream regulation of immune checkpoints is crucial to further …

Tumor-associated macrophages: An effective player of the tumor microenvironment

U Basak, T Sarkar, S Mukherjee… - Frontiers in …, 2023 - frontiersin.org
Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas

J Bao, W Lu, H Duan, Y Ye, J Li, W Liao, Y Li… - Frontiers in …, 2022 - frontiersin.org
Background Cuproptosis is a newly discovered unique non-apoptotic programmed cell
death distinguished from known death mechanisms like ferroptosis, pyroptosis, and …

Enhanced Immunogenic Cell Death and Antigen Presentation via Engineered Bifidobacterium bifidum to Boost Chemo-immunotherapy

T He, L Wang, S Gou, L Lu, G Liu, K Wang, Y Yang… - ACS …, 2023 - ACS Publications
The immunogenic cell death (ICD) of tumor cells has aroused great interest in the field of
immunotherapy, mainly due to the production of plentiful tumor-associated antigens (TAAs) …