Dendrimers are highly branched polymers with easily modifiable surfaces. This makes them
promising structures for functionalization and also for conjugation with drugs and DNA/RNA …

Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to
current treatment options. Despite major advancements in the fields of surgery and …

IKBKE is an oncogene in triple-negative breast cancer (TNBC), and we demonstrate that
IKBKE small interfering RNA (siRNA) inhibits the proliferation, migration, and invasion of …

Survivin, also known as baculoviral inhibitor of apoptosis repeat‑containing 5, is a novel
member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors …

RNA interference (RNAi) technologies have recently been developed to control a growing
number of agronomically significant fungal phytopathogens, including the white mold …

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …

Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs)
have demonstrated that variations in the shape, size, and composition lead to distinct …

Background Molecules taken up by olfactory and trigeminal nerve neurons directly access
the brain by the nose-to-brain pathway. In situ-forming mucoadhesive gels would increase …

The development of novel therapies increasingly relies on sophisticated delivery systems
that allow the drug or gene expression-modifying agent of interest entry into cells. These …

Despite the importance of siRNA delivery systems, understanding of their intracellular fate
remains elusive. We recently developed a multi-component siRNA nanocomplex to deliver …