Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

The hair follicle (HF) is a highly conserved sensory organ associated with the immune
response against pathogens, thermoregulation, sebum production, angiogenesis …

Although regeneration through the reprogramming of one cell lineage to another occurs in
fish and amphibians, it has not been observed in mammals. We discovered in the mouse …

Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

Mammalian wounds typically heal by fibrotic repair without hair follicle (HF) regeneration.
Fibrosis and regeneration are currently considered the opposite end of wound healing. This …

Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although
the mechanisms by which these changes occur are largely unknown. Here we report that the …

Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili
muscle (APM), and the sympathetic nerve, providing a model to study interactions across …

The skin forms a crucial, dynamic barrier between an animal and the external world. In
mammals, three stem cell populations possess robust regenerative potential to maintain and …

Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling
niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair …

Stem cell activity is subject to non-cell-autonomous regulation from the local
microenvironment, or niche. In adaption to varying physiological conditions and the ever …