[HTML][HTML] Pulmonary delivery of biological drugs
In the last decade, biological drugs have rapidly proliferated and have now become an
important therapeutic modality. This is because of their high potency, high specificity and …
important therapeutic modality. This is because of their high potency, high specificity and …
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …
pandemic. In this study, we used camelid immunization and proteomics to identify a large …
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2
Q Lu, J Liu, S Zhao, MFG Castro, M Laurent-Rolle… - Immunity, 2021 - cell.com
Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) engagement with immune cells, most express little, if any, of the canonical receptor of …
2) engagement with immune cells, most express little, if any, of the canonical receptor of …
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme
There are currently few approved effective treatments for SARS-CoV-2, the virus responsible
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
Advances in nanomaterial-based platforms to combat COVID-19: Diagnostics, preventions, therapeutics, and vaccine developments
The COVID-19 pandemic caused by the SARS-CoV-2, a ribonucleic acid (RNA) virus that
emerged less than two years ago but has caused nearly 6.1 million deaths to date. Recently …
emerged less than two years ago but has caused nearly 6.1 million deaths to date. Recently …
Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
COVID-19 diagnosis: current and future techniques
COVID-19 pandemic continues to be a global threat, affecting more than 200
countries/territories at both human and economic level. This necessitates the rapid …
countries/territories at both human and economic level. This necessitates the rapid …
Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy
C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …
Structural basis of SARS-CoV-2 and SARS-CoV antibody interactions
E Gavor, YK Choong, SY Er, H Sivaraman… - Trends in …, 2020 - cell.com
The 2019 coronavirus pandemic remains a major public health concern. Neutralizing
antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute …
antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute …