The differential diagnosis between obstructive and nonobstructive azoospermia is the first
step in the clinical management of azoospermic patients with infertility. It includes a detailed …

Non-Obstructive Azoospermia (NOA) affects about 1% of men in the general population and
is characterized by clinical heterogeneity implying the involvement of several different …

Spermatogenesis is a multi-step biological process where mitotically active diploid (2n)
spermatogonia differentiate into haploid (n) spermatozoa via regulated meiotic …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

Assisted reproductive technology may influence epigenetic signature as the procedures
coincide with the extensive epigenetic modification occurring from fertilization to embryo …

Reproductive aging is a natural process conserved across species and is well-known in
females. It shows age-related follicle depletion and reduction of oocyte quality, eventually …

Microdissection testicular sperm extraction (micro-TESE) is widely used to treat
nonobstructive azoospermia. However, a good prediction model is required to anticipate a …

Context Premature ovarian insufficiency (POI) and nonobstructive azoospermia (NOA) are
the most severe diseases causing irreversible infertility in females and males, respectively …

Gametes are cells that have the unique ability to give rise to new individuals as well as
transmit (epi) genetic information across generations. Generation of functionally competent …

There have been many significant scientific advances in the diagnostics and treatment
modalities in the field of male infertility in recent decades. Examples of these include …