A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …

The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …

Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …

Initially regarded as “epigenetic modifiers” acting predominantly through chromatin
remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase …

Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar
compounds that induce growth arrest in transformed cells and show promise for the …