Lipid droplets are intracellular organelles that are found in most cells, where they have
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …

Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear
membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the …

Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation,
differentiation and death. Here, starting from an unbiased metabolomics approach, we …

Background Despite advances in research on neurodegenerative diseases, the
pathogenesis and treatment response of neurodegenerative diseases remain unclear …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

Summary The mammalian Phospholipase D MitoPLD facilitates mitochondrial fusion by
generating the signaling lipid phosphatidic acid (PA). The Drosophila MitoPLD homolog …

Lipid transport between intracellular organelles is mediated by vesicular and nonvesicular
transport mechanisms and is critical for maintaining the identities of different cellular …

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between
Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the …

TP53 missense mutations leading to the expression of mutant p53 oncoproteins are frequent
driver events during tumorigenesis. p53 mutants promote tumor growth, metastasis and …