Evolutionary Computation (EC) approaches are inspired by nature and solve optimization
problems in a stochastic manner. They can offer a reliable and effective approach to address …

Orthology is a key evolutionary concept in many areas of genomic research. It provides a
framework for subjects as diverse as the evolution of genomes, gene functions, cellular …

OrthoVenn is a powerful web platform for the comparison and analysis of whole-genome
orthologous clusters. Here we present an updated version, OrthoVenn2, which provides new …

The fungal family Clavicipitaceae includes plant symbionts and parasites that produce
several psychoactive and bioprotective alkaloids. The family includes grass symbionts in the …

Gene duplication and loss is a powerful source of functional innovation. However, the
general principles that govern this process are still largely unknown. With the growing …

Background Orthology characterizes genes of different organisms that arose from a single
ancestral gene via speciation, in contrast to paralogy, which is assigned to genes that arose …

Accurate inference of orthologous genes is a pre-requisite for most comparative genomics
studies, and is also important for functional annotation of new genomes. Identification of …

Hierarchical orthologous groups are defined as sets of genes that have descended from a
single common ancestor within a taxonomic range of interest. Identifying such groups is …

Reliable orthology prediction is central to comparative genomics. Although orthology is
defined by phylogenetic criteria, most automated prediction methods are based on pairwise …

The distinction between orthologs and paralogs, genes that started diverging by speciation
versus duplication, is relevant in a wide range of contexts, most notably phylogenetic tree …