Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Dissolvable polymer microneedles for drug delivery and diagnostics

M Ali, S Namjoshi, HAE Benson, Y Mohammed… - Journal of Controlled …, 2022 - Elsevier
Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport
a wide selection of active compounds into the skin. To provide an effective therapeutic …

Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

A patch of detachable hybrid microneedle depot for localized delivery of mesenchymal stem cells in regeneration therapy

KJ Lee, Y Xue, J Lee, HJ Kim, Y Liu… - Advanced Functional …, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely used for regenerative therapy. In most
current clinical applications, MSCs are delivered by injection but face significant issues with …

Engineered microsystems for spheroid and organoid studies

SM Kang, D Kim, JH Lee, S Takayama… - Advanced healthcare …, 2021 - Wiley Online Library
Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …

Cell sheet technology: a promising strategy in regenerative medicine

M Li, JUN Ma, Y Gao, LEI Yang - Cytotherapy, 2019 - Elsevier
Regenerative medicine is a burgeoning field that is important to combat challenging
diseases and functional impairments. Compared with traditional cell therapies with evident …

[HTML][HTML] Cell sheet technology as an engineering-based approach to bone regeneration

Q You, M Lu, Z Li, Y Zhou, C Tu - International Journal of …, 2022 - ncbi.nlm.nih.gov
Bone defects that are congenital or the result of infection, malignancy, or trauma represent a
challenge to the global healthcare system. To address this issue, multiple research groups …

Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer

YB Lee, EM Kim, H Byun, H Chang, K Jeong, ZM Aman… - Biomaterials, 2018 - Elsevier
Numerous methods have been reported for the fabrication of 3D multi-cellular spheroids and
their use in stem cell culture. Current methods typically relying on the self-assembly of …

Biomimetic poly (glycerol sebacate)/poly (l-lactic acid) blend scaffolds for adipose tissue engineering

M Frydrych, S Román, S MacNeil, B Chen - Acta Biomaterialia, 2015 - Elsevier
Large three-dimensional poly (glycerol sebacate)(PGS)/poly (l-lactic acid)(PLLA) scaffolds
with similar bulk mechanical properties to native low and high stress adapted adipose tissue …

Hydrogel nanospike patch as a flexible anti-pathogenic scaffold for regulating stem cell behavior

S Park, HH Park, K Sun, Y Gwon, M Seong, S Kim… - ACS …, 2019 - ACS Publications
Vertically aligned nanomaterials, such as nanowires and nanoneedles, hold strong potential
as efficient platforms onto which living cells or tissues can be interfaced for use in advanced …