Immunology of Mycobacterium tuberculosis Infections
JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
Dynamic balance of pro‐and anti‐inflammatory signals controls disease and limits pathology
Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …
and this is especially true for infections by persistent pathogens. One mechanism that allows …
[HTML][HTML] Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in …
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in …
[HTML][HTML] Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
PL Lin, CB Ford, MT Coleman, AJ Myers, R Gawande… - Nature medicine, 2014 - nature.com
Over 30% of the world's population is infected with Mycobacterium tuberculosis (Mtb), yet
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …
Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
The absence of a gold standard to determine when antibiotics induce a sterilizing cure has
confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We …
confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We …
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
A Lenaerts, CE Barry III, V Dartois - Immunological reviews, 2015 - Wiley Online Library
Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …
types and fates of pulmonary lesions that form following infection by M ycobacterium …
[HTML][HTML] SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both …
Vaccines are urgently needed to combat the global coronavirus disease 2019 (COVID-19)
pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) …
pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) …
[HTML][HTML] Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major
cellular component of TB lung granulomas and are known to play an important role in …
cellular component of TB lung granulomas and are known to play an important role in …
Cavitary tuberculosis: the gateway of disease transmission
ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …
[HTML][HTML] Lymph nodes—The neglected battlefield in tuberculosis
Lymph nodes, particularly thoracic lymph nodes, are among the most common sites of
extrapulmonary tuberculosis (TB). However, Mycobacterium tuberculosis (Mtb) infection in …
extrapulmonary tuberculosis (TB). However, Mycobacterium tuberculosis (Mtb) infection in …