For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …

Mechanism-based therapy centred on the molecular understanding of disease-causing
pathways in a given patient is still the exception rather than the rule in medicine, even in …

Angina or ischemia with no obstructive coronary disease (ANOCA/INOCA) is a common but
under-treated condition due to poorly understood pathophysiologic mechanisms, limited …

Network medicine utilizes common genetic origins, markers and co-morbidities to uncover
mechanistic links between diseases. These links can be summarized in the diseasome, a …

Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This
review summarizes the effects of cGMP on the growth and survival of vascular smooth …

cGMP is an important signalling molecule in humans. Fluorescent cGMP biosensors have
emerged as powerful tools for the sensitive analysis of cGMP pathways at the single‐cell …

Reduced nitric oxide (NO) bioactivity in red blood cells (RBCs) is critical for augmented
myocardial ischemia-reperfusion injury in type 2 diabetes. This study identified the nature of …

Aims Aged arteries are characterized by attenuated vasodilator and enhanced
vasoconstrictor responses, which contribute to the development of diseases such as arterial …

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer.
Sanguisorba officinalis L.(SOL), a traditional Chinese herbal medicine called Diyu, has been …

GPCRs arguably represent the most effective current therapeutic targets for a plethora of
diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance …