Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …

Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

The survival rate for metastatic osteosarcoma has not improved for several decades, since
the introduction and refinement of chemotherapy as a treatment in addition to surgery. Over …

Simple Summary Osteosarcoma (OS) is the most common primary orthopedic malignancy
and typically affects children and young adults. Its lesions often metastasize to distant sites …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Bone tumours are difficult to diagnose and treat, as they are rare and over 60 different
subtypes are recognised. The emergence of next-generation sequencing has partly …

Cancer is a systemic heterogeneous disease that can undergo several rounds of latency
and activation. Tumor progression evolves by increasing diversity, adaptation to signals from …

Highlights•Osteosarcoma is a disease resulting from osteogenic differentiation
defects.•Differentiation therapy for osteosarcoma has received extensive attention.•Various …

As the essential sexual hormone, estrogen and its receptor has been proved to participate in
the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor …

Osteosarcoma is an often‐fatal mesenchyme‐derived malignancy in children and young
adults. Overexpression of EMT‐transcription factors (EMT‐TFs) has been associated with …