lipoxygenase (ALOX5) is an enzyme involved in arachidonic acid (AA) metabolism, a
metabolic pathway in which cysteinyl leukotrienes (CysLTs) are the resultant metabolites …

Although more than 100 years have passed since Alois Alzheimer reported a case of
Alzheimer's disease (AD), a definitive answer to the causes of cognitive impairment in the …

Inflammatory responses play a major role in the pathophysiology of cerebral ischemia.
Mesenchymal stem cell-derived exosomes (MSC-exos) have important anti-inflammatory …

Importance The evidence base for the association between montelukast and adverse
neuropsychiatric outcomes is mixed and inconclusive. Several methodological limitations …

Background and Aim A growing body of literature suggests the association between
dementia risk and proton pump inhibitor (PPI) use. Therefore, we aimed to investigate the …

Background: Fasudil, a Rho kinase inhibitor, exerts therapeutic effects in a mouse model of
Alzheimer's disease (AD), a chronic neurodegenerative disease with progressive loss of …

Parkinson's disease (PD) is a neurodegenerative disorder where misfolded alpha-synuclein-
enriched aggregates called Lewy bodies are central in pathogenesis. No neuroprotective or …

A novel nanocrystal system of montelukast (MTK) was designed to improve the transdermal
delivery, while ensuring chemical stability of the labile compound. MTK nanocrystal …

Background: Leukotrienes are powerful mediators of inflammation and interact with specific
receptors in target cell membrane to initiate an inflammatory response. Thus, Leukotrienes …

Currently, there is no definitive cure for epilepsy. The available medications relieve
symptoms and reduce seizure attacks. The major challenge with the available antiepileptic …