The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Mechanisms and regulation of RNA condensation in RNP granule formation

D Tauber, G Tauber, R Parker - Trends in biochemical sciences, 2020 - cell.com
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

S Kroschwald, S Maharana, D Mateju, L Malinovska… - elife, 2015 - elifesciences.org
RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein
aggregates or through phase separation into a liquid RNA/protein phase. Which model …

Stress granules and cell signaling: more than just a passing phase?

N Kedersha, P Ivanov, P Anderson - Trends in biochemical sciences, 2013 - cell.com
Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors,
and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs …

Stress granules: the Tao of RNA triage

P Anderson, N Kedersha - Trends in biochemical sciences, 2008 - cell.com
Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) are
functional byproducts of mRNA metabolism, sharing substrate mRNA, dynamic properties …

Post-transcriptional regulatory functions of mammalian pumilio proteins

AC Goldstrohm, TMT Hall, KM McKenney - TRENDS in Genetics, 2018 - cell.com
Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

[HTML][HTML] microRNAs at the synapse

G Schratt - Nature Reviews Neuroscience, 2009 - nature.com
MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene
regulation in a plethora of tissues, including the nervous system. Recent evidence points to …

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

A Tichon, N Gil, Y Lubelsky, T Havkin Solomon… - Nature …, 2016 - nature.com
Thousands of long noncoding RNA (lncRNA) genes are encoded in the human genome,
and hundreds of them are evolutionarily conserved, but their functions and modes of action …

[HTML][HTML] Neuronal RNA granules: movers and makers

MA Kiebler, GJ Bassell - Neuron, 2006 - cell.com
RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be
discussed that RNA transport and local translation in neurons may be more intimately linked …

[HTML][HTML] Dendritic mRNA: transport, translation and function

CR Bramham, DG Wells - Nature Reviews Neuroscience, 2007 - nature.com
Many cellular functions require the synthesis of a specific protein or functional cohort of
proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites …