An explorative review on advanced approaches to overcome bacterial resistance by curbing bacterial biofilm formation

F Mohamad, RR Alzahrani, A Alsaadi… - Infection and Drug …, 2023 - Taylor & Francis
The continuous emergence of multidrug-resistant pathogens evoked the development of
innovative approaches targeting virulence factors unique to their pathogenic cascade …

Understanding and targeting resistance mechanisms in cancer

ZN Lei, Q Tian, QX Teng, JND Wurpel, L Zeng… - MedComm, 2023 - Wiley Online Library
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

A comprehensive review on genomics, systems biology and structural biology approaches for combating antimicrobial resistance in ESKAPE pathogens …

P Priyamvada, R Debroy, A Anbarasu… - World Journal of …, 2022 - Springer
In recent decades, antimicrobial resistance has been augmented as a global concern to
public health owing to the global spread of multidrug-resistant strains from different ESKAPE …

In silico methods for identification of potential therapeutic targets

X Zhang, F Wu, N Yang, X Zhan, J Liao, S Mai… - Interdisciplinary …, 2022 - Springer
At the initial stage of drug discovery, identifying novel targets with maximal efficacy and
minimal side effects can improve the success rate and portfolio value of drug discovery …

In silico structure evaluation of BAG3 and elucidating its association with bacterial infections through protein–protein and host‐pathogen interaction analysis

S Basu, A Naha, B Veeraraghavan… - Journal of Cellular …, 2022 - Wiley Online Library
BAG3, a co‐chaperone protein with a Bcl‐2‐associated athanogene (BAG) domain, has
diverse functionalities in protein‐folding, apoptosis, inflammation, and cell cycle regulatory …

The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Gene interaction network studies to decipher the multi-drug resistance mechanism in Salmonella enterica serovar Typhi CT18 reveal potential drug targets

R Debroy, SK Miryala, A Naha, A Anbarasu… - Microbial …, 2020 - Elsevier
Salmonella enterica subsp. enterica serovar Typhi, a human enteric pathogen causing
typhoid fever, developed resistance to multiple antibiotics over the years. The current study …

Low-Fouling and Antibacterial Polymer Brushes via Surface-Initiated Polymerization of a Mixed Zwitterionic and Cationic Monomer

N Burmeister, E Zorn, L Preuss, D Timm, N Scharnagl… - Langmuir, 2023 - ACS Publications
The use of surface-grafted polymer brushes with combined low-fouling and antibacterial
functionality is an attractive strategy to fight biofilm formation. This report describes a new …

The revaluation of plant-derived terpenes to fight antibiotic-resistant infections

F Cappiello, MR Loffredo, C Del Plato, S Cammarone… - Antibiotics, 2020 - mdpi.com
The discovery of antibiotics has revolutionized the medicine and treatment of microbial
infections. However, the current scenario has highlighted the difficulties in marketing new …

Oil-contaminated sites act as high-risk pathogen reservoirs previously overlooked in coastal zones

X Lin, J Ma, Z Zhou, B Qiao, Y Li, W Zheng, Y Tian - Water Research, 2023 - Elsevier
In addition to the organic pollutants and disturbance to the microbial, plant and animal
systems, oil contamination can also enrich opportunistic pathogens. But little is known about …