Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

The Caprini risk assessment model (RAM) has been validated in over 250 000 patients in
more than 100 clinical trials worldwide. Ultimately, appropriate treatment options are …

BACKGROUND: Blood for transfusion is stored for up to 42 days. Older blood develops
lesions and accumulates potentially injurious substances. Some studies report increasing …

Hemorrhage is a top cause of death after injury and is the leading cause of potentially
preventable trauma deaths. 1–3 In contrast to other causes of trauma death, such as …

Venous thromboembolism (VTE) including pulmonary embolism (PE) and deep vein
thrombosis (DVT) is one of the leading causes of preventable cardiovascular disease in the …

Background Extracorporeal membrane oxygenation support (ECMO) typically requires
multiple blood transfusions and is associated with frequent bleeding complications. Blood …

Storage lesion–induced, red cell–derived microvesicles (RBC-MVs) propagate coagulation
by supporting the assembly of the prothrombinase complex. It has also been reported that …

Background Red blood cell–derived microparticles (RMP s) are small phospholipid vesicles
shed from RBCs in blood units, where they accumulate during storage. Because …

During storage of red blood cells (RBC), these cells develop storage lesions. The clinical
relevance of these storage lesions is heavily discussed in literature. In this review, different …

Red cell transfusion therapy is a common treatment modality in contemporary medical
practice. Although blood collection and administration is safer and more efficient than ever …