Regulation of heat shock transcription factors and their roles in physiology and disease
R Gomez-Pastor, ET Burchfiel, DJ Thiele - Nature reviews Molecular …, 2018 - nature.com
The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct
transcriptional activators of genes regulated by thermal stress, encoding heat shock …
transcriptional activators of genes regulated by thermal stress, encoding heat shock …
Compromised MAPK signaling in human diseases: an update
EK Kim, EJ Choi - Archives of toxicology, 2015 - Springer
The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH 2-terminal
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
AL Mahul-Mellier, J Burtscher… - Proceedings of the …, 2020 - National Acad Sciences
Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
Histamine, histamine receptors, and neuropathic pain relief
I Obara, V Telezhkin, I Alrashdi… - British Journal of …, 2020 - Wiley Online Library
Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …
physiological and pathological processes, including pain. In the last two decades, there has …
[HTML][HTML] The role of mitochondrial dysfunction in age-related diseases
RK Lane, T Hilsabeck, SL Rea - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The aging process is accompanied by the onset of disease and a general decline in
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …
Kinases control of regulated cell death revealing druggable targets for Parkinson's disease
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …
world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the …
Neuroprotection of rotenone-induced parkinsonism by ursolic acid in PD mouse model
W Zahra, SN Rai, H Birla, SS Singh… - CNS & Neurological …, 2020 - ingentaconnect.com
Background: Parkinson's Disease (PD) is characterized by both motor and non-motor
symptoms. The presynaptic neuronal protein, α-Synuclein, plays a pivotal role in PD …
symptoms. The presynaptic neuronal protein, α-Synuclein, plays a pivotal role in PD …
Differentially expressed circular RNAs in peripheral blood mononuclear cells of patients with Parkinson's disease
S Ravanidis, A Bougea, D Karampatsi… - Movement …, 2021 - Wiley Online Library
Background New noninvasive and affordable molecular approaches that will complement
current practices and increase the accuracy of Parkinson's disease (PD) diagnosis are …
current practices and increase the accuracy of Parkinson's disease (PD) diagnosis are …
LRRK2 pathways leading to neurodegeneration
MR Cookson - Current neurology and neuroscience reports, 2015 - Springer
Mutations in LRRK2 are associated with inherited Parkinson's disease (PD) in a large
number of families, and the genetic locus containing the LRRK2 gene contains a risk factor …
number of families, and the genetic locus containing the LRRK2 gene contains a risk factor …
Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress …
The organophosphate (OP) pesticide chlorpyrifos (CPF), used in agricultural settings,
induces developmental and neurological impairments. Recent studies using in vitro cell …
induces developmental and neurological impairments. Recent studies using in vitro cell …