Diversity and function of group 1 innate lymphoid cells
Innate lymphoid cells (ILCs) are a heterogeneous population of cells with diverse roles in
immune responses. Three major groups of ILCs have been defined on the basis of similarity …
immune responses. Three major groups of ILCs have been defined on the basis of similarity …
Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease
S Bolivar-Wagers, JH Larson, S Jin… - Frontiers in …, 2022 - frontiersin.org
Regulatory T-cells (Treg) are critical for the maintenance of immune homeostasis and
tolerance induction. While the immunosuppressive mechanisms of Treg have been …
tolerance induction. While the immunosuppressive mechanisms of Treg have been …
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells
J Corria-Osorio, SJ Carmona, E Stefanidis… - Nature …, 2023 - nature.com
To date, no immunotherapy approaches have managed to fully overcome T-cell exhaustion,
which remains a mandatory fate for chronically activated effector cells and a major …
which remains a mandatory fate for chronically activated effector cells and a major …
[PDF][PDF] Imageable antigen‐presenting gold nanoparticle vaccines for effective cancer immunotherapy in vivo
IH Lee, HK Kwon, S An, D Kim, S Kim… - Angewandte Chemie …, 2012 - academia.edu
Vaccination with the aid of adjuvants is a highly effective therapeutic option for the
prevention of various diseases.[1] However, development of vaccines against existing …
prevention of various diseases.[1] However, development of vaccines against existing …
[HTML][HTML] Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy
The efficacy of combined near-infrared (NIR) and immune therapies for inhibiting tumor
growth and recurrence has gained increasing research attention. Regulatory T cells in the …
growth and recurrence has gained increasing research attention. Regulatory T cells in the …
Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells
L Lin, J Couturier, X Yu, MA Medina, CA Kozinetz… - BMC immunology, 2014 - Springer
Abstract Background Granzyme B (GrzB) is a serine proteinase expressed by memory T
cells and NK cells. Methods to measure GrzB protein usually involve intracellular (flow …
cells and NK cells. Methods to measure GrzB protein usually involve intracellular (flow …
Intestinal barrier interactions with specialized CD8 T cells
Š Konjar, C Ferreira, B Blankenhaus… - Frontiers in …, 2017 - frontiersin.org
The trillions of microorganisms that reside in the gastrointestinal tract, essential for nutrient
absorption, are kept under control by a single cell barrier and large amounts of immune …
absorption, are kept under control by a single cell barrier and large amounts of immune …
Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells
After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases
called granzymes in conjunction with perforin, allowing granzymes to enter and kill target …
called granzymes in conjunction with perforin, allowing granzymes to enter and kill target …
Are all granzymes cytotoxic in vivo?
LT Joeckel, PI Bird - Biological chemistry, 2014 - degruyter.com
Granzymes are serine proteases mainly found in cytotoxic lymphocytes. The most-studied
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …
Hepatosplenic and hepatocytotropic T-cell lymphoma: two distinct types of T-cell lymphoma in dogs
The clinical, clinicopathologic, and pathological findings of 9 dogs with T-cell lymphoma that
involved the liver in the absence of peripheral lymphadenopathy were assessed. Seven …
involved the liver in the absence of peripheral lymphadenopathy were assessed. Seven …