The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the
'apicoplast'. The discovery of the apicoplast ushered in an exciting new prospect for drug …

Mitochondria in malaria parasites have some unusual evolutionary and functional features.
The drastic reduction in the size of their mitochondrial genome, encoding just three proteins …

Using an active approach to preventing biofilm formation, we implemented a microfluidic
bioreactor that enables long-term culture and monitoring of extremely small populations of …

Background The carbon metabolism of the blood stages of Plasmodium falciparum,
comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be …

Intracellular malaria parasites require lipids for growth and replication. They possess a
prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid …

Intracellular pathogens have devised mechanisms to exploit their host cells to ensure their
survival and replication. The malaria parasite Plasmodium falciparum relies on an exchange …

We report the genome sequence of Theileria parva, an apicomplexan pathogen causing
economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited …

The mitochondrion of Plasmodium species is a validated drug target. However, very little is
known about the functions of this organelle. In this review, we utilize data available from the …

SUMMARY Lipoic acid [(R)-5-(1, 2-dithiolan-3-yl) pentanoic acid] is an enzyme cofactor
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …

Apicomplexan parasites are the cause of numerous important human diseases including
malaria and AIDS-associated opportunistic infections. Drug treatment for these diseases is …