Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Prostate cancer (PCa) is the most common malignant tumor with a high global incidence in
males. The mechanism underlying PCa progression is still not clear. This study observed …

Preclinical models of cancer have long been paramount to understanding tumor
development and advancing the treatment of cancer. Creating preclinical models that mimic …

Pancreatic cancer is a major cause of demise worldwide. Although key associated genetic
changes have been discovered, disease progression is sustained by pathogenic …

Abstract Neuropilin‐2 (NRP2) is a multifunctional protein engaged in the regulation of
angiogenesis, lymphangiogenesis, axon guidance, and tumor metastasis, but its function in …

The success of immunotherapy for cancer treatment is limited by the presence of an
immunosuppressive tumor microenvironment (TME); Therefore, identifying novel targets to …

Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue
homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility …

Simple Summary Dysregulation of molecular mechanisms that regulate nervous system
development may be at the origin of brain tumors. We reviewed the role of neuropilin-1 …