Despite the lack of endogenous chitin synthesis, mammalian genomes encode two
enzymatically active true chitinases (chitotriosidase and acidic mammalian chitinase) and a …

COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and
patients with comorbid diseases (CM). Because chitinase 3-like-1 (CHI3L1) is induced …

Abstract Background Chitinase-3-like protein-1 (CHI3L1), also known as human cartilage
glycoprotein-39 (HC-gp39), plays a role in several biological processes, including oxidative …

Chitin, a polysaccharide found in the fungal cell wall and the exoskeletons of house dust
mites and cockroaches, has garnered attention as a potential immunoreactive allergen …

Introduction Data from patient cohorts and mouse models of atopic dermatitis, food allergy
and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic …

Timely treatment of acute inflammatory reactions induced by fungi or bacteria is essential to
prevent infectious damage. Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor which is …

Leukemia stem cells in acute myeloid leukemia (AML) can persist within unique bone
marrow niches similar to those of healthy hematopoietic stem cells and resist chemotherapy …

Asthma is one of the most common noncommunicable diseases in the world. Approximately
30% of severe cases are associated with fungal sensitization, often associated with allergy …

Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma
strongly support a role for the chitinase-like protein ChI3L1 in allergic disease. To address …