The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …

Bosetti et al NINDS Workshop Recommendations 2633 academia, industry, the Food and
Drug Administration, and other public and private funding agencies. In the context of this …

The relationship between biomechanical forces and neuropathology is key to understanding
traumatic brain injury. White matter tracts are damaged by high shear forces during impact …

Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the
measurement of dysfunctional anxiety behavioral states following experimental TBI in …

Unique from other brain disorders, traumatic brain injury (TBI) generally results from a
discrete biomechanical event that induces rapid head movement. The large size and high …

Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain
trauma that uses a pneumatically or electromagnetically controlled piston to induce …

Closed-head traumatic brain injury (TBI) is a worldwide concern with increasing prevalence
and cost to society. Rotational acceleration is a primary mechanism in TBI that results from …

Despite the large number of promising neuroprotective agents identified in experimental
traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long …