Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy
S Li, A Wang, Y Wu, S He, W Shuai… - Immunological …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …
Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives
MM Faheem, ND Seligson, SM Ahmad, RU Rasool… - Cell death …, 2020 - nature.com
Drug induced resistance is a widespread problem in the clinical management of cancer.
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …
Effective drug concentration and selectivity depends on fraction of primitive cells
Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has
been driving the search for more active and specific compounds. In this work, we show how …
been driving the search for more active and specific compounds. In this work, we show how …
Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma
MM Radspieler, M Schindeldecker… - Oncology …, 2019 - spandidos-publications.com
Clear-cell renal cell carcinoma (ccRCC) is a von-Hippel-Lindau gene (VHL) associated
tumor disease. In addition to activating the hypoxia inducible factor (HIF) dependent oxygen …
tumor disease. In addition to activating the hypoxia inducible factor (HIF) dependent oxygen …
Quadra-stable dynamics of p53 and PTEN in the DNA damage response
Cell fate determination is a complex process that is frequently described as cells traveling on
rugged pathways, beginning with DNA damage response (DDR). Tumor protein p53 (p53) …
rugged pathways, beginning with DNA damage response (DDR). Tumor protein p53 (p53) …
[HTML][HTML] Cellular senescence in non-small cell lung cancer
H Zhu, J Sun, C Zhang, P Li, C Tan, M Yang… - Frontiers in Bioscience …, 2023 - imrpress.com
Lung cancer has the highest mortality rate amongst all malignancies worldwide, and is the
second-highest incidence of cancer in women. Non-small cell lung cancer (NSCLC) is …
second-highest incidence of cancer in women. Non-small cell lung cancer (NSCLC) is …
Phytol and (−)-α-bisabolol Synergistically trigger intrinsic apoptosis through redox and Ca2+ imbalance in non-small cell lung cancer
C Kiruthiga, DJ Balan, S Jafni, DP Anandan… - Biocatalysis and …, 2024 - Elsevier
This study aimed to identify a combination of natural compounds that could enhance lung
cancer treatment by targeting multiple pathways and reducing toxicity. The Chow-Talay …
cancer treatment by targeting multiple pathways and reducing toxicity. The Chow-Talay …
Anticancer Activity and Mode of Action of Cu(II), Zn(II), and Mn(II) Complexes with 5-Chloro-2-N-(2-quinolylmethylene)aminophenol
S Gai, L He, M He, X Zhong, C Jiang, Y Qin, M Jiang - Molecules, 2023 - mdpi.com
Developing a new generation of anticancer metal-based drugs that can both kill tumor cells
and inhibit cell migration is a promising strategy. Herein, we synthesized three Cu (II), Zn (II) …
and inhibit cell migration is a promising strategy. Herein, we synthesized three Cu (II), Zn (II) …
Hepatic ischemia-reperfusion impairs blood-brain barrier partly due to release of arginase from injured liver
L Zhu, H Zhou, F Xu, H Yang, P Li, Y Sheng… - Frontiers in …, 2021 - frontiersin.org
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain.
The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed …
The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed …
Tackling aging by using miRNA as a target and a tool
WF Lai, M Lin, WT Wong - Trends in molecular medicine, 2019 - cell.com
miRNA is a class of short noncoding RNA that regulates gene expression at the post-
transcriptional level. Evidence of age-associated changes in miRNA expression has been …
transcriptional level. Evidence of age-associated changes in miRNA expression has been …