Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Glutamate acts on postsynaptic glutamate receptors to mediate excitatory communication
between neurons. The discovery that additional presynaptic glutamate receptors can …

Transient receptor potential (TRP) cation channels are renowned for their ability to sense
diverse chemical stimuli. Still, for many members of this large and heterogeneous protein …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

Chronic retinal inflammation in the form of activated microglia and macrophages are
implicated in the etiology of neurodegenerative diseases of the retina, including age-related …

Neuroactive steroids refer to steroids that are capable of regulating neuronal activities.
Neuroactive steroids, synthesized either de novo in the nervous tissue or in the peripheral …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

Spike timing-dependent plasticity (STDP) is a Hebbian learning rule important for synaptic
refinement during development and for learning and memory in the adult. Given the …

Neurosteroids are a relatively new class of neuroactive compounds brought to prominence
in the past 2 decades. Despite knowing of their presence in the nervous system of various …

Neurosteroids are synthesized de novo in the nervous system; they mainly moderate
neuronal excitability, and reach target cells via the extracellular pathway. The synthesis of …