What have organoids and assembloids taught us about the pathophysiology of neuropsychiatric disorders?

RJ Levy, SP Paşca - Biological Psychiatry, 2023 - Elsevier
Neuropsychiatric research has been impeded by limited access to human brain tissue,
especially from early stages of neurodevelopment when the pathophysiology of many …

[HTML][HTML] Beyond consciousness: Ethical, legal, and social issues in human brain organoid research and application

M Kataoka, T Niikawa, N Nagaishi, TL Lee… - European Journal of …, 2024 - Elsevier
This study aims to provide a comprehensive review of the ethical, legal and social issues in
human brain organoid research, with a view to different types of research and applications …

Collaborative ethics: innovating collaboration between ethicists and life scientists

JE Lunshof, J Rijssenbeek - Nature Methods, 2024 - nature.com
Scientific breakthroughs can change how we understand and live in the world, disrupting
long-held assumptions and concepts and raising new questions for philosophy and science …

Modeling brain disorders using transplanted organoids: beyond the short circuit

S Velasco - Cell Stem Cell, 2022 - cell.com
Human cortical organoids transplanted into the somatosensory cortex of rats integrate into
the host neural circuits, receive inputs from host cells, and can produce behavioral …

Stem cell ethics and policy: What's old is new again

I Hyun - Med, 2022 - cell.com
Stem cells are increasingly being used to model human development and disease in the
form of self-organizing embryo models, brain organoids, and neurological chimeras. These …

Human brain organoids and their ethical issues: Navigating the moral and social challenges between hype and underestimation

A Lavazza, AA Chinaia - EMBO reports, 2024 - embopress.org
Since the field of neuroethics was estab-lished in the early 2000s, some scholars have
proposed to distinguish between anticipatory and speculative neuroethics (Wexler, 2019) …

Pioneering neurohackers: between egocentric human enhancement and altruistic sacrifice

G Seyfried, S Youssef, M Schmidt - Frontiers in Neuroscience, 2023 - frontiersin.org
The growing field of neurotechnology (NT) is becoming more and more accessible in terms
of reduced costs, increasing availability and reliability of materials, and ways to implant …

From an ethics 'side dish'to 'your modus operandi': neurotechnology researcher perspectives on the impacts of a decade of embedded ethics collaboration

PA Tubig, TE Brown, D McCusker, M Pham… - Journal of …, 2024 - Taylor & Francis
In this paper, we discuss ethics integration and consider questions about evaluating the
success of such efforts by reporting qualitative data from an interview study with researchers …

The End of Personification: The Mereological Fallacy in Science Communication on Brain Organoids

SAL van Till, EM Bunnik - The American Journal of Bioethics, 2024 - Taylor & Francis
In the last two decades, stem cell-based brain organoids have been developed to study
disease mechanisms in various neurological, psychiatric, and developmental disorders …

Too-Many-Oids: the paradox in constructing an organoid ethics framework

AJ Barnhart, K Dierickx - Molecular Psychology: Brain …, 2023 - molecularpsychology.org
Background: The field of organoid ethics is complex and multifaceted, and the need for
flexibility and adaptability in the face of its moral complexity is of great importance. Certain …