Fibronectin (FN) is a multidomain protein with the ability to bind simultaneously to cell
surface receptors, collagen, proteoglycans, and other FN molecules. Many of these domains …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

Via integrins, cells can sense dimensionality and other physical and biochemical properties
of the extracellular matrix (ECM). Cells respond differently to two-dimensional substrates …

Unlike adult mammals, adult zebrafish vigorously regenerate lost heart muscle in response
to injury. The epicardium, a mesothelial cell layer enveloping the myocardium, is activated to …

The formation and maintenance of boundaries between neighbouring groups of embryonic
cells is vital for development because groups of cells with distinct functions must often be …

The body axis of vertebrate embryos is periodically segmented into bilaterally symmetric
pairs of somites,. The anteroposterior length of somites, their position and left–right …

A promising therapeutic strategy for diverse genetic disorders involves transplantation of
autologous stem cells that have been genetically corrected ex vivo. A major challenge in …

The establishment and maintenance of precisely organized tissues requires the formation of
sharp borders between distinct cell populations. The maintenance of segregated cell …

Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three
types of repeating modules: FN-I, FN-II, and FN-III. The interactions of α5β1 or αv integrins …

The metameric pattern of somites is created based on oscillatory expression of clock genes
in presomitic mesoderm. However, the mechanism for converting the dynamic oscillation to …