Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
Adrenergic regulation of calcium channels in the heart
Each heartbeat is initiated by the action potential, an electrical signal that depolarizes the
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …
CaMKII signaling in heart diseases: emerging role in diabetic cardiomyopathy
Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …
Calcium signaling in cardiomyocyte function
G Gilbert, K Demydenko, E Dries… - Cold Spring …, 2020 - cshperspectives.cshlp.org
Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …
RyR2 and calcium release in heart failure
JP Benitah, R Perrier, JJ Mercadier, L Pereira… - Frontiers in …, 2021 - frontiersin.org
Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia
JA Keefe, OM Moore, KS Ho, XHT Wehrens - Archives of toxicology, 2023 - Springer
Abstract Calcium (Ca2+) ions are a key second messenger involved in the rhythmic
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …
Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring
M Takenaka, M Kodama, T Murayama… - Molecular …, 2023 - ASPET
Type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic
(ER)/sarcoplasmic reticulum that plays a central role in the excitation-contraction coupling in …
(ER)/sarcoplasmic reticulum that plays a central role in the excitation-contraction coupling in …
Spatial and temporal crosstalk between the cAMP and Ca2+ signaling systems
V Arige, DI Yule - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2022 - Elsevier
The ubiquitous secondary messengers, Ca 2+ and cAMP, play a vital role in shaping a
diverse array of physiological processes. More significantly, accumulating evidence over the …
diverse array of physiological processes. More significantly, accumulating evidence over the …
Caveolae-associated cAMP/Ca2+-mediated mechano-chemical signal transduction in mouse atrial myocytes
Caveolae are tiny invaginations in the sarcolemma that buffer extra membrane and
contribute to mechanical regulation of cellular function. While the role of caveolae in …
contribute to mechanical regulation of cellular function. While the role of caveolae in …
Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage
The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …