Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
Deciphering miRNAs' action through miRNA editing
M Correia de Sousa, M Gjorgjieva, D Dolicka… - International journal of …, 2019 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene
expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) …
expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) …
Extracellular miRNAs: from biomarkers to mediators of physiology and disease
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …
The pathogenesis of endometriosis: molecular and cell biology insights
The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
Classical and noncanonical functions of miRNAs in cancers
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …
progression of human cancers. The molecular events responsible for the widespread …
The role and mechanisms of action of microRNAs in cancer drug resistance
W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …
can regulate various target genes and are thus involved in the regulation of a variety of …
The roles of microRNAs in epigenetic regulation
MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in
length, now recognized as one of the major regulatory gene families in eukaryotes. Recent …
length, now recognized as one of the major regulatory gene families in eukaryotes. Recent …
Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
Non-coding RNAs and ferroptosis: potential implications for cancer therapy
Ferroptosis is a recently defined form of regulated cell death, which is biochemically and
morphologically distinct from traditional forms of programmed cell death such as apoptosis …
morphologically distinct from traditional forms of programmed cell death such as apoptosis …
Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …