Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Deciphering miRNAs' action through miRNA editing

M Correia de Sousa, M Gjorgjieva, D Dolicka… - International journal of …, 2019 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene
expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) …

Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

The pathogenesis of endometriosis: molecular and cell biology insights

AS Laganà, S Garzon, M Götte, P Viganò… - International journal of …, 2019 - mdpi.com
The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …

Classical and noncanonical functions of miRNAs in cancers

MP Dragomir, E Knutsen, GA Calin - Trends in Genetics, 2022 - cell.com
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …

The role and mechanisms of action of microRNAs in cancer drug resistance

W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

The roles of microRNAs in epigenetic regulation

Q Yao, Y Chen, X Zhou - Current opinion in chemical biology, 2019 - Elsevier
MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in
length, now recognized as one of the major regulatory gene families in eukaryotes. Recent …

Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer

WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Non-coding RNAs and ferroptosis: potential implications for cancer therapy

A Balihodzic, F Prinz, MA Dengler, GA Calin… - Cell Death & …, 2022 - nature.com
Ferroptosis is a recently defined form of regulated cell death, which is biochemically and
morphologically distinct from traditional forms of programmed cell death such as apoptosis …

Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles

JP Bost, H Barriga, MN Holme, A Gallud, M Maugeri… - ACS …, 2021 - ACS Publications
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …