ABSTRACT A handful of core intercellular signaling pathways play pivotal roles in a broad
variety of developmental processes. It has remained puzzling how so few pathways can …

Kinetic proofreading (KPR) has been used as a paradigmatic explanation for the high
specificity of ligand discrimination by cellular receptors. KPR enhances the difference in the …

Cells adapt to changing environments by sensing ligand concentrations using specific
receptors. The accuracy of sensing is ultimately limited by the finite number of ligand …

To perform their functions in the environment, and in cell collectives, living cells require
sensing of external molecular environment via cell surface receptors. In recent years …

Many quorum sensing microbes produce more than one chemical signal and detect them
using interconnected pathways that crosstalk with each other. While there are many …

Molecular Communications (MC) is a bio-inspired communication technique that uses
molecules to transfer information among bio-nano devices. In this paper, we focus on the …

Cell fate decisions in the fly embryo are rapid: hunchback genes decide in minutes whether
nuclei follow the anterior/posterior developmental blueprint by reading out positional …

Quorum sensing (QS), a dynamic microbial communication mechanism, has been widely
applied to synthetic biology for different functions. The incorporation of genome-scale …

Rationally controlling cellular metabolism is of great importance but challenging owing to its
highly complex and chaotic nature. Natural existing sensory proteins like histidine kinases …

Biological sensory receptors provide excellent examples of microscopic scale information
transduction amidst stochastic noise. We argue that stochasticity is not always a hindrance …