The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

It is unsurprising that our understanding of the role of selenium in neurological function is
somewhat immature, considering its relatively recent discovery as an essential element to …

Context: Epidemiological studies have supported the premise that an adequate selenium
intake is essential for thyroid gland function. Objective: The objective was to investigate …

The early diagnosis of osteoarthritis (OA) can halt or delay the progression of the disease,
and it is essentially beneficial to its treatment. However, biomarkers with sufficient sensitivity …

Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

Thioredoxin system is a ubiquitous disulfide reductase system evolutionarily conserved
through all living organisms. It contains thioredoxin (Trx), thioredoxin reductase (TrxR) and …

Chronic metabolic stress leads to cellular dysfunction, characterized by excessive reactive
oxygen species, endoplasmic reticulum (ER) stress and inflammation, which has been …

The Michael reaction is a conjugate addition and is one of the most powerful methods with
which to prepare functional molecules with a β‐stereogenic center. Despite its success in …

Selenoprotein K (SELENOK) is a major part of selenoprotein family. Selenoproteins have
been proven playing vital roles in a variety of physiological processes. However, as a …

Selenocysteine (Sec) is a primary kind of reactive selenium species in cells whose
antioxidant roles in a series of liver diseases have been featured. However, it is difficult to …