Updated international consensus report on the investigation and management of primary immune thrombocytopenia

D Provan, DM Arnold, JB Bussel, BH Chong… - Blood …, 2019 - ashpublications.org
Over the last decade, there have been numerous developments and changes in treatment
practices for the management of patients with immune thrombocytopenia (ITP). This article is …

Splenectomy for immune thrombocytopenia: down but not out

S Chaturvedi, DM Arnold… - Blood, The Journal of the …, 2018 - ashpublications.org
Splenectomy is an effective therapy for steroid-refractory or dependent immune
thrombocytopenia (ITP). With the advent of medical alternatives such as rituximab and …

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

J Li, DE Van Der Wal, G Zhu, M Xu, I Yougbare… - Nature …, 2015 - nature.com
Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by
autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests …

Immune thrombocytopenia-current diagnostics and therapy: recommendations of a joint working group of DGHO, ÖGHO, SGH, GPOH, and DGTI

A Matzdorff, O Meyer, H Ostermann, V Kiefel… - Oncology research and …, 2018 - karger.com
Immune thrombocytopenia (ITP) is a rare disorder and meets the criteria for an orphan
disease. Expertise in the management of these patients is not widely spread. The following …

How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment

W Ghanima, B Godeau, DB Cines… - Blood, The Journal of …, 2012 - ashpublications.org
The paradigm for managing primary immune thrombocytopenia (ITP) in adults has changed
with the advent of rituximab and thrombopoietin receptor agonists (TPO-RAs) as options for …

Pathophysiology of immune thrombocytopenia

J Li, JA Sullivan, H Ni - Current opinion in hematology, 2018 - journals.lww.com
Recent evidence of distinct ITP pathophysiology has opened new exploratory avenues for
disease management. We will discuss the utility of investigations into these mechanisms of …

State of the art–how I manage immune thrombocytopenia

N Cooper - British journal of haematology, 2017 - Wiley Online Library
The management of patients with immune thrombocytopenia (ITP) is rapidly evolving. Over
the last 15 years, a number of novel treatments have improved practice, with many steroid …

Current management of primary immune thrombocytopenia

D Provan, AC Newland - Advances in therapy, 2015 - Springer
Primary immune thrombocytopenia is an autoimmune disorder of unknown cause affecting
both children and adults. The low peripheral blood platelet count is caused by premature …

[HTML][HTML] Splenectomy as a curative treatment for immune thrombocytopenia: a retrospective analysis of 233 patients with a minimum follow up of 10 years

N Vianelli, F Palandri, N Polverelli, R Stasi… - …, 2013 - ncbi.nlm.nih.gov
The treatment of choice in steroid-resistant immune thrombocytopenia is still controversial
due to the recent advent of new drugs (anti-CD20 antibodies and thrombopoietin mimetics) …

A critical appraisal of the evidence for the role of splenectomy in adults and children with ITP

F Rodeghiero - British journal of haematology, 2018 - Wiley Online Library
In primary chronic immune thrombocytopenia, long‐term response to splenectomy, with 60%
of patients enjoying a treatment‐free life, is higher when compared with rituximab and …