Ultra‐high dose rate dosimetry: challenges and opportunities for FLASH radiation therapy

F Romano, C Bailat, PG Jorge, MLF Lerch… - Medical …, 2022 - Wiley Online Library
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …

A roadmap to clinical trials for FLASH

PA Taylor, JM Moran, DA Jaffray… - Medical …, 2022 - Wiley Online Library
While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …

[HTML][HTML] The European Joint Research Project UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

A Schüller, S Heinrich, C Fouillade, A Subiel… - Physica Medica, 2020 - Elsevier
UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse
dose rates is a recently started European Joint Research Project with the aim to develop and …

Development of an ultra‐thin parallel plate ionization chamber for dosimetry in FLASH radiotherapy

F Gómez, DM Gonzalez‐Castaño… - Medical …, 2022 - Wiley Online Library
Background Conventional air ionization chambers (ICs) exhibit ion recombination correction
factors that deviate substantially from unity when irradiated with dose per pulse magnitudes …

FLASH radiotherapy with electrons: issues related to the production, monitoring, and dosimetric characterization of the beam

F Di Martino, P Barca, S Barone, E Bortoli… - Frontiers in …, 2020 - frontiersin.org
Various in vivo experimental works carried out on different animals and organs have shown
that it is possible to reduce the damage caused to healthy tissue still preserving the …

Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry

M Marinelli, G Felici, F Galante, A Gasparini… - Medical …, 2022 - Wiley Online Library
Purpose FLASH radiotherapy (RT) is an emerging technique in which beams with ultra‐high
dose rates (UH‐DR) and dose per pulse (UH‐DPP) are used. Commercially available active …

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

A Lourenço, A Subiel, N Lee, S Flynn, J Cotterill… - Scientific Reports, 2023 - nature.com
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short
pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly …

Toward an effective use of laser-driven very high energy electrons for radiotherapy: Feasibility assessment of multi-field and intensity modulation irradiation schemes

L Labate, D Palla, D Panetta, F Avella, F Baffigi… - Scientific reports, 2020 - nature.com
Radiotherapy with very high energy electrons has been investigated for a couple of decades
as an effective approach to improve dose distribution compared to conventional photon …

[HTML][HTML] A new solution for UHDP and UHDR (Flash) measurements: Theory and conceptual design of ALLS chamber

F Di Martino, D Del Sarto, MG Bisogni, S Capaccioli… - Physica Medica, 2022 - Elsevier
Ultra-High dose-per-pulse regimens (UHDP), necessary to trigger the “FLASH” effect, still
pose serious challenges to dosimetry. Dosimetry plays a crucial role, both to significantly …

Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art

P Chaudhary, G Milluzzo, H Ahmed, B Odlozilik… - Frontiers in …, 2021 - frontiersin.org
The use of particle accelerators in radiotherapy has significantly changed the therapeutic
outcomes for many types of solid tumours. In particular, protons are well known for sparing …