Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating
blood vessel formation and barrier function. Proper composition and function of the …

Eph receptor tyrosine kinases, together with their cell surface-anchored ephrin ligands,
constitute an important cell–cell communication system that regulates physiological and …

Cell–cell communication is mediated by membrane receptors and their ligands, such as the
Eph/ephrin system, orchestrating cell migration during development and in diverse cancer …

Background Mesothelioma is an aggressive disease with limited therapeutic options. The
growth factor progranulin plays a critical role in several cancer models, where it regulates …

Solid epithelial cancers with significant desmoplasia are characterized by an excessive
deposition of collagen-based matrix, which often supports tumor progression. However, the …

Purpose: Epithelial cells in the equatorial region of the ocular lens undergo a remarkable
transition from randomly packed cells into precisely aligned and hexagon-shaped cells …

Cardiovascular diseases (CVDs) pose a significant global health threat due to their complex
pathogenesis and high incidence, imposing a substantial burden on global healthcare …

Background Major therapeutic developments have been made in the prevention of head
and neck cancer (HNC), and crucial measures have been implemented for the survival of …

Upon injury, fibroblasts in the surrounding tissue become activated, migrating into the
wound in a controlled manner. Once they arrive, they contract the wound and remodel the …