The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo

J Castillo, M Jodar, R Oliva - Human reproduction update, 2018 - academic.oup.com
BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …

Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo

H Yang, D Bai, Y Li, Z Yu, C Wang, Y Sheng, W Liu… - Nature cell …, 2022 - nature.com
Parental DNA methylation and histone modifications undergo distinct global reprogramming
in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its …

Genomic imprinting effects on complex traits in domesticated animal species

AM O'Doherty, DE MacHugh, C Spillane… - Frontiers in …, 2015 - frontiersin.org
Monoallelically expressed genes that exert their phenotypic effect in a parent-of-origin
specific manner are considered to be subject to genomic imprinting, the most well …

[HTML][HTML] Prenatal exposure to triclosan assessed in multiple urine samples and placental DNA methylation

P Jedynak, L Broséus, J Tost, F Busato, S Gabet… - Environmental …, 2023 - Elsevier
A previous study reported positive associations of maternal urinary concentrations of
triclosan, a synthetic phenol with widespread exposure in the general population, with …

Pregnancy exposure to synthetic phenols and placental DNA methylation—An epigenome-wide association study in male infants from the EDEN cohort

P Jedynak, J Tost, AM Calafat, E Bourova-Flin… - Environmental …, 2021 - Elsevier
In utero exposure to environmental chemicals, such as synthetic phenols, may alter DNA
methylation in different tissues, including placenta—a critical organ for fetal development …

[HTML][HTML] The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

I Sandovici, A Georgopoulou, V Pérez-García… - Developmental Cell, 2022 - cell.com
In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but
whether and how the latter adapts to putative fetal signals is currently unknown. Here, we …

Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific …

H Liu, X Liu, S Zhang, J Lv, S Li, S Shang… - Nucleic acids …, 2016 - academic.oup.com
DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular
eukaryotes. Although various human cell types may have the same genome, these cells …

Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation

C Wang, C Chen, X Liu, C Li, Q Wu, X Chen, L Yang… - Cell Research, 2022 - nature.com
Chromatin remodeling is essential for epigenome reprogramming after fertilization.
However, the underlying mechanisms of chromatin remodeling remain to be explored. Here …

Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions

S Rousseaux, E Seyve, F Chuffart, E Bourova-Flin… - BMC medicine, 2020 - Springer
Background Although exposure to cigarette smoking during pregnancy has been associated
with alterations of DNA methylation in the cord blood or placental cells, whether such …

EmExplorer: a database for exploring time activation of gene expression in mammalian embryos

B Hu, L Zheng, C Long, M Song, T Li… - Open …, 2019 - royalsocietypublishing.org
Understanding early development offers a striking opportunity to investigate genetic
disease, stem cell and assisted reproductive technology. Recent advances in high …