The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo
BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …
understand reproductive functions. Most of the sperm proteins are related to …
Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo
Parental DNA methylation and histone modifications undergo distinct global reprogramming
in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its …
in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its …
Genomic imprinting effects on complex traits in domesticated animal species
Monoallelically expressed genes that exert their phenotypic effect in a parent-of-origin
specific manner are considered to be subject to genomic imprinting, the most well …
specific manner are considered to be subject to genomic imprinting, the most well …
[HTML][HTML] Prenatal exposure to triclosan assessed in multiple urine samples and placental DNA methylation
A previous study reported positive associations of maternal urinary concentrations of
triclosan, a synthetic phenol with widespread exposure in the general population, with …
triclosan, a synthetic phenol with widespread exposure in the general population, with …
Pregnancy exposure to synthetic phenols and placental DNA methylation—An epigenome-wide association study in male infants from the EDEN cohort
P Jedynak, J Tost, AM Calafat, E Bourova-Flin… - Environmental …, 2021 - Elsevier
In utero exposure to environmental chemicals, such as synthetic phenols, may alter DNA
methylation in different tissues, including placenta—a critical organ for fetal development …
methylation in different tissues, including placenta—a critical organ for fetal development …
[HTML][HTML] The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
I Sandovici, A Georgopoulou, V Pérez-García… - Developmental Cell, 2022 - cell.com
In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but
whether and how the latter adapts to putative fetal signals is currently unknown. Here, we …
whether and how the latter adapts to putative fetal signals is currently unknown. Here, we …
Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific …
DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular
eukaryotes. Although various human cell types may have the same genome, these cells …
eukaryotes. Although various human cell types may have the same genome, these cells …
Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
Chromatin remodeling is essential for epigenome reprogramming after fertilization.
However, the underlying mechanisms of chromatin remodeling remain to be explored. Here …
However, the underlying mechanisms of chromatin remodeling remain to be explored. Here …
Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions
S Rousseaux, E Seyve, F Chuffart, E Bourova-Flin… - BMC medicine, 2020 - Springer
Background Although exposure to cigarette smoking during pregnancy has been associated
with alterations of DNA methylation in the cord blood or placental cells, whether such …
with alterations of DNA methylation in the cord blood or placental cells, whether such …
EmExplorer: a database for exploring time activation of gene expression in mammalian embryos
Understanding early development offers a striking opportunity to investigate genetic
disease, stem cell and assisted reproductive technology. Recent advances in high …
disease, stem cell and assisted reproductive technology. Recent advances in high …