Cellular magnesium homeostasis

AMP Romani - Archives of biochemistry and biophysics, 2011 - Elsevier
Magnesium, the second most abundant cellular cation after potassium, is essential to
regulate numerous cellular functions and enzymes, including ion channels, metabolic …

[HTML][HTML] Mitochondrial channels: ion fluxes and more

I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Lactate elicits ER-mitochondrial Mg2+ dynamics to integrate cellular metabolism

CC Daw, K Ramachandran, BT Enslow, S Maity… - Cell, 2020 - cell.com
Mg 2+ is the most abundant divalent cation in metazoans and an essential cofactor for ATP,
nucleic acids, and countless metabolic enzymes. To understand how the spatio-temporal …

Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel

M Li, Y Li, Y Lu, J Li, X Lu, Y Ren, T Wen… - Nature …, 2023 - nature.com
Abstract Mitochondrial RNA splicing 2 (Mrs2), a eukaryotic CorA ortholog, enables Mg2+ to
permeate the inner mitochondrial membrane and plays an important role in mitochondrial …

Structure of a bacterial multidrug ABC transporter

RJP Dawson, KP Locher - Nature, 2006 - nature.com
Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across
cell membranes. This is clinically relevant, as tumour cells may become resistant to agents …

Magnesium transport and function in plants: the tip of the iceberg

O Shaul - Biometals, 2002 - Springer
The maintenance of Mg 2+ homeostasis in the plant is essential for viability. This review
describes Mg 2+ functions and balancing in plants, with special focus on the existing …

[HTML][HTML] Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7

C Schmitz, AL Perraud, CO Johnson, K Inabe… - Cell, 2003 - cell.com
TRPM7 is a polypeptide with intrinsic ion channel and protein kinase domains whose
targeted deletion causes cells to experience growth arrest within 24 hr and eventually die …

Bacterial Mg2+ Homeostasis, Transport, and Virulence

EA Groisman, K Hollands, MA Kriner… - Annual review of …, 2013 - annualreviews.org
Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical
for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and …

Structural and functional comparison of magnesium transporters throughout evolution

GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

Role of magnesium in alleviation of aluminium toxicity in plants

J Bose, O Babourina, Z Rengel - Journal of experimental botany, 2011 - academic.oup.com
Magnesium is pivotal for activating a large number of enzymes; hence, magnesium plays an
important role in numerous physiological and biochemical processes affecting plant growth …