Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid
neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where …

The lack of sufficient intratumoral CD8+ T lymphocytes is a significant obstacle to effective
immunotherapy in cancer. High endothelial venules (HEVs) are organ-specific and …

It is now admitted that the immune system plays a major role in tumor control. Besides the
existence of tumor-specific T cells and B cells, many studies have demonstrated that high …

Stromal cells have for a long time been viewed as structural cells that support distinct
compartments within lymphoid tissues and little more. Instead, an active cross-talk between …

Secondary lymphoid organs (SLOs) are important initiators and regulators of immunity. To
carry out this function, the blood vasculature must deliver oxygen and nutrients and recruit …

Within secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and
targeting reticular cells is a potential strategy for controlling pathogenic lymphocytes in …

Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor,
type I interleukin 1 receptor (IL-1R1). Most previous studies have focused on the expression …

Lymph node (LN) expansion during an immune response relies on the transient remodeling
of its vasculature. Although the mechanisms driving LN endothelial cell division are …